Peptides & Peptide Synthesis Products
Fmoc-Asp(OtBu)-OH
Catalog No: 41019
Nα-Fmoc-L-aspartic acid 4-tert-butyl ester, CAS: 71989-14-5, MW: 411.45, Formula: C23H25NO6
Nα-Fmoc-L-aspartic acid 4-tert-butyl ester, CAS: 71989-14-5, MW: 411.45, Formula: C23H25NO6
$8.00
SKU
41019
Fmoc-Asp(OtBu)-OH
Nα-Fmoc-L-aspartic acid β-tert-butyl ester
The standard aspartic acid derivative for Fmoc/tBu SPPS. The tert-butyl ester protects the side-chain carboxyl during chain assembly and is removed in the final TFA cleavage.
Repeated piperidine treatment can cyclize aspartic acid to an aspartimide, especially in Asp-Gly, Asp-Asn and Asp-Ser sequences and at higher temperatures. Adding 0.1 M HOBt or a little formic acid to the piperidine solution reduces it.
Applications
- Routine incorporation of aspartic acid in Fmoc SPPS
- RGD and other aspartate-containing motifs
- Automated, microwave and fast-flow synthesis
Storage
Store refrigerated (2–8 °C) in a tightly closed container, and let it reach room temperature before opening.
Published research using P3 BioSystems material
- Lu C et al. Simultaneous extraction and detection of peptides, steroids, and proteins in small tissue samples. Frontiers in Endocrinology 2023. doi:10.3389/fendo.2023.1266985
- Hoekstra M et al. Evaluation of Jumonji C lysine demethylase substrate preference to guide identification of in vitro substrates. STAR Protocols 2022. doi:10.1016/j.xpro.2022.101271
References
- Mergler M et al. The aspartimide problem in Fmoc‐based SPPS. Part I. Journal of Peptide Science 2003, 9, 36–46. doi:10.1002/psc.430
For research use only. Not for human or veterinary use.
| Catalog Number | 41019 |
|---|---|
| CAS | 71989-14-5 |
| M.W. | 411.45 |
| Formula | C23H25NO6 |
| IUPAC Name | (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid |
| Synonym | Nα-Fmoc-L-aspartic acid 4-tert-butyl ester |
| Also Known As |
|
| InChIKey | FODJWPHPWBKDON-IBGZPJMESA-N |
| InChI | InChI=1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1 |
| SMILES | CC(C)(C)OC(=O)C[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13 |
The current Safety Data Sheet for Fmoc-Asp(OtBu)-OH (Catalog No: 41019).
The Certificate of Analysis for each lot of Fmoc-Asp(OtBu)-OH (Catalog No: 41019). Enter the lot number printed on the product label.
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