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Catalog No: 31007
High Purity >99%, (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, CAS: 156311-83-0, MW: 521.38, Formula: C17H27F6N7OP2

PyAOP >99% Pure (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

The coupling agent PyAOP is a derivative of the HOAt family useful in preparing a range of difficult peptides especially amino acids of a hindered nature. An advantage of this uronium salt is that it can be used in greater excesses and does not under go detrimental side reactions at the amino terminus which blocks further assembly of a Fmoc amino acids(1.).

The pyrrolidino derivatives like PyAOP appear to be the reagent of choice relative to the piperidino compounds or those formed from trialkylamines. Further it has been determined that the various other aminium/onium salts (HOAt and HOBt) should be used for the activation of hindered species, since the latter may lead to the formation of guanidino derivatives (2.).

1. Fernando Albericio, Marta Cases, Jordi Alsina, Salvadore Triolo, Louis Carpino and Steven Kates. Tetrahedron Letters, Volume 38, Issue 27, 7 July 1997 Pages 4853-4856.
2. Fernando Albericio, Josep Bofill. Ayman El-Faham and Steven Kates, J. Org Chem. 1998; 63(26) pp 978-9683. The Journal of Organic Chemistry, 1998, 63 (26) Pages 9678-9683.

More Information
Catalog Number 31007
CAS 156311-83-0
M.W. 521.38
Formula C17H27F6N7OP2
IUPAC Name tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphanium hexafluorophosphate
Synonym (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
Also Known As
  • tripyrrolidin-1-yl-(triazolo[5,4-b]pyridin-3-yloxy)phosphanium hexafluorophosphate
  • tripyrrolidin-1-yl-(triazolo[5,4-b]pyridin-3-yloxy)phosphonium hexafluorophosphate
  • tri1-pyrrolidinyl-(3-triazolo[5,4-b]pyridinyloxy)phosphonium hexafluorophosphate
  • tripyrrolidin-1-yl-([1,2,3]triazolo[5,4-b]pyridin-3-yloxy)phosphanium hexafluorophosphate
InChI InChI=1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1
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