Rink Amide MBHA Resin
4-(2′,4′-Dimethoxyphenyl-Fmocaminomethyl) -phenoxyacetamidomethylbenzhydryl amine resin
100-200 mesh, 0.3-0.8 mMol/g
Rink Amide MBHA Resin
This resin is less acid sensitive than Rink Amide resin because the benzhydrylamine linker is joined to the support through an electron-withdrawing acetamido spacer [1]. Normally the product is detached from the resin using 95% TFA in DCM plus scavengers as required by the composition of the substrate [1, 2]. It is also useful for preparing peptides. Boussard, Cyrille et al. has reported that synthesis of tri- and tetra- and pentapeptides were performed via a solid phase synthesis methodology using a Rink Amide MBHA resin [3].
[1] Bernatowicz, M. S., Daniel, S. B., Koster, H., Tetrahedron Lett., 1989, 30, 4645
[2] M. Lebl, et al., J. Comb. Chem., 1999, 1, 474
[3] Boussard, Cyrille, et al., European Journal of Medicinal Chemistry, 2002, 37(11), pp, 883-890
| Catalog Number | 52002 |
|---|---|
| Synonym | 4-(2′,4′-Dimethoxyphenyl-Fmocaminomethyl) -phenoxyacetamidomethylbenzhydryl amine resin |
| Mesh Size | 100-200 |
| Substitution (mMol/g) | 0.3-0.8 |